European Food Safety Authority (EFSA) is the keystone of European Union (EU) risk assessment regarding food and feed safety. In close collaboration with national authorities and in open consultation with its stakeholders, EFSA provides independent scientific advice and clear communication on existing and emerging risks. Following a request from the European Commission, the European Food Safety Authority (EFSA), carried out a revised exposure assessment of steviol glycosides from its use as a food additive, for children and adults, based on the revised proposed uses presented in the terms of reference.
January 2011:  STATEMENT OF EFSA: Revised exposure assessment for steviol glycosides for the proposed uses as a food additive Considering the available toxicity data (in vitro and in vivo animal studies and some human tolerance studies), the EFSA Panel on Food Additives and Nutrient Sources added to Food concluded that steviol glycosides (comprising not less than 95% of the following steviol glycosides: stevioside, rebaudiosides A, B, C, D, E and F, steviolbioside, rubusoside and dulcoside A), are not carcinogenic, genotoxic or associated with any reproductive/ developmental toxicity. The Panel established an ADI for steviol glycosides, expressed as steviol equivalents, of 4 mg/kg bw/day based on application of a 100-fold uncertainty factor to the NOAEL in the 2-year carcinogenicity study in the rat of 2.5% stevioside in the diet. This is equal to 967 mg stevioside/kg bw/day (corresponding to approximately 388 mg steviol equivalents/kg bw/day).
April 2010: EFSA evaluates the safety of steviol glycosides
March 2010: Scientific Opinion on the safety of steviol glycosides for the proposed uses as a food additive